Mcq Subject: Biochemistry

After a point mutation, glutamic acid is replaced by valine, which leads to formation of sickle cell hemoglobin. The mobility of HbS as compared with normal hemoglobin on gel electrophoresis will be:

A. Decreased

B. Increased

C. Dependent on HbS concentration

D. Unchanged.

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Which of the following amino acids is quickly converted to tyrosine?

A. Arginine

B. Glycine

C. Phenylalanine

D. Leucine

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During exercise, the most rapid way to synthesize ATP is:

A. Glycogenolysis

B. Glycolysis

C. TCA cycle

D. Creatine phosphate

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Thiamine deficiency decreases cellular metabolism because:

A. Thiamine is a coenzyme for pyruvate dehydrogenase and alfa-ketoglutarate dehydrogenases

B. Activity of transketolase is inhibited

C. It is required for the process of transamination

D. It is a cofactor in oxidative reduction

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An adolescent male patient came with pain in calf muscles on exercise. On biopsy excessive amount of glycogen present was found to be present in the muscle. What is the most likely enzyme deficiency?

A. Muscle debranching enzyme

B. Phosphofructokinase I

C. Glucose 6 phosphatase

D. Phosphorylase enzyme

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The amino acid, which is used in the estimation of collagen is:

A. Hydroxyproline

B. Proline

C. Lysine

D. Glycine

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Which of the following type of collagen is present in healing and granulation tissue?

A. Type I

B. Type II

C. Type III

D. Type IV

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Restriction endonuclease cuts at

A. AAGGAA

B. AAGAAG

C. AAGTTC

D. AAGCTT

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Biomarker of alcoholic hepatitis:

A. ALP

B. AST

C. LDH

D. GGT

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In CRISPR-Cas 9 system, which repair mechanism is used for genome editing?

A. Non homologous end repair

B. Homologous repair

C. Mismatch repair

D. Nucleotide excision repair

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