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862 Anaesthesia

Cardiac or central nervous system toxicity may result when standard lidocaine doses are administered to patients with circulatory failure. This may be due to the following reason:

ALidocaine concentration are initially higher in relatively well perfused tissues such as brain and hea
BHistamine receptors in brain and hea gets suddenly activated in circulatory failure
CThere is a sudden out-burst of release of adreneline, noradreneline and dopamine in brain and hea
DLidocaine is conveed into a toxic meta-bolite due to its longer stay in liver.
Anaesthesia
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