In Takayasu infiltrates of mucosa and submucosa of stomach is characteristically seen in Eosinophilic gastroenteritis.
Correct Answer: Subclavian artery
Description: (Refer: Robbins Pathologic Basis of Disease, 8thedition, pg no: 513-514)
Takayasu arteritis (PULSELESS DISEASE)
Granulomatous vasculitis of medium and larger arteries.
Ocular disturbances.
Diminished pulses in the upper extremities.
Transmural fibrous thickening of the aorta (aortic arch andgreat vessels).
Aortic lesions share many attributes with giant-cell aortitisincluding clinical features and histology; indeed, the distinctionis typically made only on the basis of the age of the patient.
In age > 50 years designated as giant-cell aortitis, while thoseunder 50 have Takayasu arteritis.
Morphology - Irregular thickening of the vessel wall with intimal hyperplasia
Histological appearance
Adventitial mononuclear infiltrates.
Perivascular cuffing of the vasa vasorum.
Mononuclear inflammation in the media.
Granulomatous inflammation and Giant cells.
Patchy medial necrosis.
In late stages, collagenous scarring, with admixed chronic inflammatory infiltrates, occurs in all three layers of the vessel wall.
Aortic root involvement causes aortic insufficiency.
Frequency of Arteriography Abnormalities in Takayasu’sArteritis
Category:
Unknown
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