The treatment for a case of virilizing adrenal hyperplasia is :
Correct Answer: None of these
Description: Coisone In a case of virilising adrenal hyperplasia there is a block in the biosynthesis of coicosteroids which leads to increased ACTH. which inturn leads to increased androgen and therefore virilisation. This defect can be corrected by administering coisone ,hydrocoisone or synthetic coicosteroids (like prednisone or prednisolone) which will effectively control the excess production of ACTH. It is most satisfactory to begin treatment with relatively larger doses of hydrocoisone divided in three doses orally for 7-10 days to obtain rapid suppression of adrenal activity. In younger infants the initial dose is about 25mg/day, and in adults 100mg/day. In newborn with CAH with defect in electrolyte regulation, it is usually necessary to administer NaCI in amounts of 4-6gm/day either orally or parenterally in addition to coisone. Besides this : -- Phallus should be removed surgically (by age of 5 years). -- Mc lndoe's vaginoplasty should be done.
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Gynaecology & Obstetrics
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