Pro-apoptotic gene and anti-apoptotic gene belong to which gene family?
Correct Answer: Bcl
Description: * The major mechanism of intrinsic mitochondrial pathway of apoptosis is by pro- and anti-apoptotic members of bcl proteins.* Bcl protein was first detected on B cell lymphoma and hence its name.* It is located on mitochondrial inner membrane and regulates cell growth and cell death.* Pro-apoptotic mechanisms can damage mitochondrial membranes and allow leakage of cytochrome C into the cytoplasm. Cytochrome C is the lifeline of intact mitochondria.Growth promoter/anti-apoptotic proteinsPro-apoptotic proteinsBcl-2, Bcl-X and Mcl-1Bim, Bad and Bid
Category:
Pathology
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