All of the following genetic mutations are associated with an increased risk of deep venous thrombosis, EXCEPT:
Correct Answer: Glycoprotein 1b platelet receptor
Description: Affecting procoagulant or fibrinolytic pathways: The most common inherited risk factors for venous thrombosis are the factor V Leiden mutation and prothrombin 20210 mutation. Other mutations predisposing an individual to venous thrombosis include inherited deficiency of protein C or S and mutations of fibrinogen, tissue plasminogen activator, thrombomodulin, or plasminogen activator inhibitor. In contrast, aerial thrombosis occurs in the setting a platelet activation, and the genetic predisposition for aerial thrombosis includes mutations that affect platelet receptors or redox enzymes. The glycoprotein 1b platelet receptor mutation would increase the risk of aerial thrombosis. Ref: Goldhaber S.Z. (2012). Chapter 262. Deep Venous Thrombosis and Pulmonary Thromboembolism. In D.L. Longo, A.S. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, J. Loscalzo (Eds), Harrison's Principles of Internal Medicine, 18e.
Category:
Medicine
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now