In drug metabolism, hepatic cytochrome P-450 system is responsible for:

A. Phase I reactions (hydrolysis, oxidation, reduction etc.) only

B. Phase II reactions (conjugation, synthesis etc.) only

C. Both phase I and II reactions

D. Converting hydrophilic metabolites to lipophilic metabolites

Correct Answer: Phase I reactions (hydrolysis, oxidation, reduction etc.) only

Description: Ans. (A) Phase I reactions (hydrolysis, oxidation, reduction etc. only(Ref: Katzung 13th/e p60; KDT 8th/e p32)Cytochrome P450 enzymes are responsible for phase I reactions only whereas microsomal enzymes can be involved in phase II also (glucuronide conjugation)

Category: Pharmacology

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