All are true regarding chloroquine, EXCEPT :
Correct Answer: Acts only on exo erythrocytic cycle
Description: Ans. is 'a' acts only on exoerythrocytic cycle.]Reference KDT 5th p. 739 (4th page 793)]Chloroquine is a rapidly acting erythrocytic schizonticide. It is active against all species of plasmodium.It has no effect on pre and exoerythrocytic phase of the parasite.Mechanism of action of chloroquine :|First chloroquine is concentrated inside infected erythrocytes. (Higher cone in infected RBC).|Prevents the polymerization of heme into hemozoin|Heme damages the plasmodium membrane.About choice "B" K.D.T. says -" The earlier hypothesis that chloroquine acts by interfering with DNA function is now considered untenable"
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