In a child with acute liver failure, the most impoant abnormal serum biochemical test that indicates poor prognosis:
Correct Answer: Increasing prothrombin time
Description: Definition of Acute liver failure in children includes: Biochemical evidence of acute liver injury (usually <8 wk duration); No evidence of chronic liver disease; Hepatic-based coagulopathy defined as i) a prothrombin time (PT) >15 sec or international normalized ratio (INR) >1.5 not corrected by vitamin K in the presence of clinical hepatic encephalopathy, or ii) a PT >20 sec or INR >2 regardless of the presence of clinical hepatic encephalopathy. Hepatic synthetic function is reflected in serum albumin and protein levels and in the PT or INR Unresponsiveness of PT to vitamin K suggests severe hepatic disease Serum aminotransferase activities do not correlate well with the severity of the illness.
Category:
Pediatrics
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now