Anti-PLA2R antibody is commonly found in which of the following renal diseases?
Correct Answer: Membranous nephropathy
Description: Antibodies against PLA2R antigen is found in most cases of primary membranous nephropathy. Anti-GBM disease: Antibodies against NC1 domain of type IV collagen antigen, cause of crescentic glomerulonephritis, linear IgG deposits along GBM in IF Dense deposit disease: Acquired or genetic dysregulation of the alternative complement pathway, C3 deposits in IF, dense deposits on electron microscopy) Focal segmental glomerulosclerosis: Cause of nephrotic syndrome, podocyte injury is implicated in pathogenesis, microscopy shows focal and segmental sclerosis and hyalinosis in the glomeruli, IgM+C3 deposits in IF
Category:
Pathology
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