A four-year-old child is diagnosed with Duchennemuscular dystrophy, an X-linked recessive disorder. Genetic analysis shows that the patient’s gene for the muscle protein dystrophin contains a mutation in its promoter region. What would be the most likely effect of this mutation?
Correct Answer: Initiation of dystrophin transcription will be deficient.
Description: Initiation of dystrophin transcription will be deficient Transcription of DNA gene into RNA is a 4 step process involving: Initiation, Elongation, Termination and Posttranscriptional modification (capping, splicing, addition of poly-A tail) The 'promoter' region of DNA is responsible for initiation of the RNA transcription, hence any mutation in this region is going to effect the initiation process of mRNA. (Transcription is an impoant topic and a detailed study from standard textbooks is a must; an easy and good explanation is given in Lippincott)
Category:
Biochemistry
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now