Person having heterozygous sickle cell trait is protected from infection of-
Correct Answer: Plasmodium falciparum
Description: Protection against plasmodium falciparum is obtained by Metabolically active intracellular parasites consume oxygen and decrease intracellular pH, both of which promote Hb sickling in AS red cells.These distoed and stiffened cells may be cleared more rapidly by phagocytes in spleen and liver helping to keep parasite load down Another effect of sickling is that it impairs the formation of membrane knobs containing a protein made by the parasite called PfEMP -1.Thesemembrane knobs are implicated in adhesion of infected red cells to endothelium which is believed to have an impoant pathogenic role in the most severe form of the disease cerebral malaria Ref: Robbins and Cotran Pathologic basis of disease.South Asia Edition -9;volume 1.page no. 635
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now