Eculizumab is used in treatment of:
Correct Answer: Paroxysmal nocturnal hemoglobinuria
Description: Eculizumab is a humanized IgG monoclonal antibody that binds the C5 complement component, inhibiting its cleavage into C5a and C5b thereby inhibiting the terminal pore-forming lytic activity of complement. Eculizumab is approved for patients with paroxysmal nocturnal hemoglobinuria (PNH) and dramatically reduces the need for red blood cell transfusions. Ref: Katzung 11th edition Chapter 61.
Category:
Pharmacology
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