True about membranous GN are following except –
Correct Answer: Deposition between endothelium and B.M.
Description: Membranous glomerulonephritis
Membranous glomerulonephritis, also known as membranous nephropathy, is a slowly progressive disease of the kidney affecting mostly patients between ages of 30 and 50 years.
Membranous glomerulonephritis is classified
Primary (idiopathic) - 85%
Secondary - 15%
Drugs → Penicillamine, captopril, gold, NSAIDS
Malignant tumors → Lung, colon, melanoma
Autoimmune conditions → SLE, thyroiditis
Infections → HBC, HCV, syphilis, schistosomiasis, malaria
Membranous glomerulonephritis is characterized by -
Diffuse thickening of the glomerular capillary wall.
Accumulation of electron - dense, immunoglobulin containing deposits along subepithelial side (between epithelium and GBM).
Membranous glomerulonephritis is the most common cause of nephrotic syndrome in adults.
Category:
Pathology
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