In which of the following disorders, administration of barbiturates is contraindicated?
Correct Answer: Acute intermittent porphyria
Description: Ans. (B) Acute intermittent porphyria(Ref: KDT 8/e p427)Barbiturates induce the rate limiting enzyme 'd-aminolaevulanic acid synthase' in porphyrin synthesis. This increased synthesis of porphyrins can precipitate acute attack of AIP.
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