Enalapril increases the level of:
Correct Answer: Bradykinin
Description: Enalapril is an ACE inhibitor and the adverse effect profile of all ACE inhibitors is similar. One side effect is cough in the patients taking ACE inhibitor.
A persistent brassy cough occurs in 10- 16% patients within 1- 8 weeks, often requires discontinuation of the drug-subsides 4- 6 days thereafter. It is not dose related and appears to be caused by inhibition of bradykinin/substance P breakdown (which leads to increase in levels of Bradykinin) in the lungs of susceptible individuals.
Reference: Essentials of Medical Pharmacology Eighth Edition KD TRIPATHI page no 531
Category:
Pharmacology
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