Cyclic AMP increase the rate of glycogenolysis by

A. Promoting the formation of phosphorylase

B. Acting as a cofactor for glycogen phosphorylase

C. Furnishing phosphate for the phosphorylysis of glycogen

D. Acting as a precursor of 5' AMP which is a cofactor for glycogen phosphorylase

Correct Answer: Promoting the formation of phosphorylase

Description: The roles of cAMP and inorganic phosphate (Pi) in the regulation of muscle glycogenolysis during exercise have been investigated in humans using the needle biopsy technique. The fraction of phosphorylase a in resting muscle was as a mean 23%, but the rate of glycogenolysis was extremely low. Epinephrine infusion increased cAMP in muscle by 3-fold and transformed 80% of phosphorylase to the form

Category: Biochemistry

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