Racemic mixture of two enantiomers with different pharmaeokinetic and pharmacodynamic propeies is seen in –
Correct Answer: Verapamil
Description: Ans. is 'c' i.e., Verapamil " Verapamil is prescribed as a racemate, L-Verapamil is a more potent calcium channel blocker than is dverapamil. However with oral therapy, the 1-enantiomer undergoes more extensive first - pass hepatic metabolism. For this reason, a given concentration of verapamil prolongs the PR interval to a greater extent when the drug is administered intravenously (where concentrations of the 1-and d-enantiomers are equivalent) than when it is administered orally."
Category:
Pharmacology
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