Which of the following statements about Hemochromatosis is true?
Correct Answer: Inherited as an autosomal recessive disorder
Description: Hemochromatosis is an autosomal recessive disease caused by a mutation in the HFE gene on chromosome 6. The HFE protein plays an impoant role in the process by which duodenal crypt cells sense body iron stores, leading in turn to increased iron absorption from the duodenum. A decrease in the synthesis or expression of hepcidin, a principal iron regulatory hormone, is a key pathogenic factor in all forms of hemochromatosis. About 85% of persons are homozygous for the C282Y mutation. Ref: Current Medical Diagnosis and Treatment, 2012, Chapter 16
Category:
Medicine
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now