When activated by b-adrenergic receptors, the G protein:
Correct Answer: Activates adenylate cyclase
Description: When norepinephrine binds to a beta-adrenergic receptor, it activates a G protein (i.e., a guanosine triphosphate (GTP) binding protein), which, in turn, activates adenylate cyclase. Adenylate cyclase catalyzes the formation of cyclic adenosine 3',5'-monophosphate (cAMP), which activates a variety of kinases. One of these kinases (protein kinase A) phosphorylates phospholamban, which reduces the inhibition of the sarcoplasmic reticular Ca2+ pump, increasing sequestration of Ca2+ from the cytoplasm. Ref: Biaggioni I., Robeson D. (2012). Chapter 9. Adrenoceptor Agonists & Sympathomimetic Drugs. In B.G. Katzung, S.B. Masters, A.J. Trevor (Eds),Basic & Clinical Pharmacology, 12e.
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now