A patient of Alzheimer’s disease is on rivastigmine therapy and develops symptoms of depression. Use of which of the following drug would decrease efficacy of rivostigmine –
Correct Answer: TCAs
Description: Ans. is 'a' i.e., TCAs o Cholinergic transmission is diminished in Alzheimer's disease. o All agents that benefit the conduction act to enhance acetyhcholine activity by inhibition of the acetylcholinesterase which metabolises and inactivates acetylcholine. o Consequently acetylcholine remains usable for longer. o Rivastigmine acts in similar way. o Tricyclic antidepressants (TCAs) have anticholinergic propey, therefore they counteract that cholinergic effect of rivastigmine.
Category:
Pharmacology
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