Myocardial isonzyme of CK which is specific for myocardial infarction is
Correct Answer: CK-MB
Description: within 4–6 hrs after development of acute MI, peaks during the 2nd day (4 fold rise) and disappears in 2–3 days. Other causes of total CK elevation:
1. Skeletal diseases – Polymyositis, Muscle dys- trophy, Myopathies
2. Electrical cardioversion
3. Skeletal muscle damage – trauma, convulsions, immobilisation
4. Hypothyroidism
5. Stroke 6. Surgery b. AST: Starts rising on the 1st day, peaks in 2–3 days (3 fold rise) and disappears by 3rd day.
c. LDH1: Starts rising by second day, peaks around 3– 4 days ( 3 fold rise) and disappears in 10 days. d. Troponin T: Cardiac troponin T is a regulatory contractile protein not normally found in blood. Its detection in the circulation has been shown to be a sensitive and specific marker for myocardial cell damage.
Troponin T and I reach a reliable diagnostic level in plasma by 12-16 hrs, maximal activity by 24-32 hrs, returns to normal in 10-12 days. Troponin I : 0-0.4 ng/ml Troponin T: 0-0.1 ng/ml Cardiac troponins are detected in the serum by using monoclonal antibodies.
These antibodies have negligible cross reactivity to skeletal muscle. Cardiac troponins I and T start to rise within 3-4 hours after myocardial infarction and remain raised for 4-10 days
Category:
Medicine
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