The following monoclonal antibody is directed against alpha 4 integrin?
Correct Answer: Natalizumab
Description: NatalizumabNatalizumab is a humanized IgG4 monoclonal antibody that binds to the a4-subunit of a4b1 and a4b7 integrins expressed on the surfaces of all leukocytes except neutrophils and inhibits the a4-mediated adhesion of leukocytes to their cognate receptor. It is indicated for patients with multiple sclerosis and Crohn's disease who have not tolerated or had inadequate responses to conventional treatments.Ref: Katzung 13th ed.pg 993.
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now