Gastrointestinal stromal tumor (GIST) occur from mutation of-
Correct Answer: c-KIT oncogene
Description: GIST is the most common mesenchymal tumor of the abdomen PATHOGENESIS Approximately 75% to 80% of all GISTs have oncogenic, gain-of-function mutations of the gene encoding the tyrosine kinase c-KIT, which is the receptor for stem cell factor. Another 8% of GISTs have mutations that activate a related tyrosine kinase, platelet-derived growth factor receptor A (PDGFRA); thus activating mutations in tyrosine kinases are found in viually all GISTs. However, either mutation is sufficient for tumorigenesis, and c-KIT and PDGFRA mutations are almost never found in a single tumor. GISTs appear to arise from, or share a common stem cell with, the interstitial cells of Cajal, which express c-KIT, are located in the muscularis propria, and serve as pacemaker cells for gut peristalsis. TEXT BOOK OF ROBBINS BASIC PAYHOLOGY NINTH EDITION PAGE.572 IMAGE REF:
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now