Which is the most common side effect of Dapagliflozin?
Correct Answer: All of the above
Description: Causes all of the effects. DAPAGLIFLOZIN An SGLT-2 inhibitor drug of gliflozin class. Used in type 2 diabetes treatment. MECHANISM OF ACTION: Glucose is reabsorbed completely in proximal tubules by sodium-glucose cotranspoer-2 . Dapagliflozin acts by inhibiting SGLT-2 transpoer. Effects: Single daily dose produces round-the-clock glucosuria lowering blood glucose levels. SIDE EFFECTS: Main effects: Heavy glycosuria (Up to 70 grams/day). Causes rapid weight loss & tiredness. Increased incidence of urinary tract infections & genital infections (candidiasis). Because increased urinary glucose worsens infections already associated with diabetes. Increased risk of diabetic ketoacidosis. Increased urinary frequency. Other effects: Decreases bone mineral density ----> Increases risk of fractures. Higher rates of breast & bladder cancers repoed. Hypotensive reactions.
Category:
Pharmacology
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