Which of the following is not caused by furosemide?
Correct Answer: Hypercalcemia
Description: Furosemide increases Ca2+ excretion (contrast to thiazides which reduce it) as well as Mg++ excretion by abolishing the lumen positive transepithelial potential difference in the TAL which drives reabsorption of these divalent cations. Furosemide tends to raise blood uric acid level by competing with its proximal tubular secretion as well as by increasing reabsorption in PT that occurs as a consequence of reduced ECF volume. The magnitude of hyperuricaemia is lower than that with thiazides. A small rise in blood sugar level may be noted after regular use of furosemide, but this is again less marked compared to thiazides.
Thick ascending limb of Loop of Henle = TAL.
Reference: Essentials of Medical Pharmacology Eighth Edition KD TRIPATHI page no 627
Category:
Pharmacology
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