The phase I reactions of drug metabolism include the following except:
Correct Answer: Conjugation
Description: Biotransformation reactions can be classified into:
Nonsynthetic/Phase 1/Functionalization reactions:
A functional group (- OH, -COOH, -CHO, H2, - SH) is generated or exposed- metabolite may be active or inactive.
Synthetic / Conjugation / Phase lI reactions:
An endogenous radical is conjugated to the drug- metabolite is mostly inactive; except few drugs, e.g. glucuronide conjugate of morphine and sulfate conjugate of minoxidil are active.
Certain drugs already have functional groups and are directly conjugated, while others undergo a phase I reaction first followed by a phase II reaction.
Category:
Pharmacology
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