True statement about clonidine are all except ?
Correct Answer: Prazosin is used to antagonize side effects of clonidine
Description: Ans. is 'd' i.e., Prazosin is used to antagonize side effects of clonidine Clonidine is an a-2 agonist, while prazosin blocks the a-1 receptors. o Clonidine enhances vagal tone (parasympathetic outflow) which can cause bradycardia. o The major haemodynamic effects result from stimulation of a2a receptors present mainly postjunctionally in medulla --> decrease sympathetic outflow --> fall in BP and bradycardia. o Clonidine is used in hypeension.
Category:
Pharmacology
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