First step in cholesterol synthesis is inhibited by ?
Correct Answer: Lovastatin
Description: Ans. is 'd' i.e., Lovastatin Statins (Lovastatin) competitively inhibit the conversion of HMG-CoA to mevalonate (rate limiting step in cholesterol synthesis) by inhibiting the enzyme HMG-CoA reductase.Hvpolipidemic drugs HMG-CoA reductase inhibitors (statins) - Lovastatin, Simvastatin, Pravastatin, Atorvastatin, Rosuvastatin.Bile acid sequestrants (Resins) - cholestyramine, colestipol.Activate lipoprotein lipase (fabric acid derivatives) - clofibrate, gemfibrozil, bezafibrate, fenofibrate. 4.Inhibit lipolysis and triglyceride synthesis - Nicotinic acid.Other - Probucol, Gugulipid, Ezetimibe, Avasimibe, Torcetrapib.Ezetimibe inhibits intestinal cholesterole absorption.Avasimibe inhibits enzyme acyl Coenzyme A : cholesterol acyl transferase-1 (A CAT-1) which causes esterification of cholesterol.Torcetrapib inhibits cholesterol ester triglyceride transpo protein -4 T HDL cholesterol.
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now