A patient on alcohol dependence was given a drug & to avoid alcohol as drug interaction would lead to adverse drug reaction ?
Correct Answer: Disulfiram
Description: Ans. is 'a' i.e., Disulfiram The most commonly used aversive drug for alcohol abuse is disulfiram. Normally alcohol is metabolized by oxidation in liver. Alcohol Aldehyde Ethyl alcohol - Acetaldehyde - Acetate - CO2 + H2O dehydrogenase dehydrogenase Disulfiram inhibits the enzyme aldehyde dehydrogenase When alcohol is ingested after taking disulfiram, the concentration of acetaldehyde in tissues and blood rises and a number of highly distressing symptoms (aldehyde syndrome) are produced -4 Flushing, burning sensation, throbbing headache, perspiration, uneasiness, tightness in chest, dizziness, vomiting, visual disturbances, mental confusion, postural fainting and circulatory collapse. Inhibition of aldehyde dehydrogenase with disulfiram is irreversible, synthesis of fresh enzyme is required for return of activity.
Category:
Psychiatry
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now