Which of the following undergoes Hoffmann elimination?
Correct Answer: Atracurium
Description: Atracurium is a bis-benzyltetrahydroisoquinolinium with isoquinolinium nitrogens connected by a diester-containing hydrocarbon chain. The presence (in duplicate) of two-carbon separations between quaternary nitrogen and ester carbonyl provides the basis for a Hofmann elimination reaction. Fuhermore, it can undergo ester hydrolysis. In a Hofmann elimination reaction, a quaternary ammonium group is conveed to a teiary amine by cleavage of a carbon-nitrogen bond. Ref: Miller's Anesthesia 7th Ed , Chapter 29.
Category:
Anaesthesia
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now