Enzyme involved in cleavage of glycine in liver mitochondria is
Correct Answer: Dihydrolipoyl
Description: Starvation. All the three amino acids undergo similar sequence of reactions. These are summarized in Table 16.2. In this pathway, the second enzyme is a branched chain alpha-keto acid dehydrogenase. It is a complex of decarboxylase, transacylase and dihydrolipoyl dehydrogenase. So, this resembles pyruvate dehydrogenase Only liver mitochondria contain glutamate dehydrogenase (GDH) which deaminates glutamate to alpha-ketoglutarate plus ammonia. So, all amino acids are first transaminated to glutamate, which is then finally deaminated (transamination)Ref: DM Vasudevan, Page no: 200
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Biochemistry
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