Method of prevention of GVHD in bone marrow transplantation is?
Correct Answer: All of the above
Description: Treatments used to prevent GVHD include
1) Prior immunosuppression
Ciclosporin is used most commonly. This drug works by reducing the number of T cells in donated marrow or stem cells. Started a couple of days before transplant and continued for about 6 months after the transplant.
Other drugs used are- MMF, tacrolimus, sirolimus
2) T cell depletion from the marrow or stem cells
Removal of T cells from donor's bone marrow after it has been donated, or during the donation of stem cells. This method is not commonly used.
3) Treatment after transplant
Low doses of the chemotherapy drug methotrexate to suppress your immune system. This helps to keep the t cells down and so stops them attacking body cells. Cyclophosphamide is also used.
Category:
Pathology
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