Cizotinib is inhibitor of which receptor ?
Correct Answer: Tyrosine kinase
Description: Ans. is 'a'i.e., Tyrosine kinaseRefCardio - oncology: principles, prevention and management, by puja Mehta, p. 10)CrizotinibIt is a small molecule multitargeted tyrosine kinase receptor inhibitor targeting ALK, MET, ROS1 kinases.By inhibiting ALK tyrosine kinase activity, crizotinib inhibits cell proliferation, induces Gl - S phase cell cycle arrest and apoptosis.It is approved for the first line in the management of metastatic non-small cell lung cancer with an ALK mutation.
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