Reverse cholesterol transport is done by:
Correct Answer: HDL
Description: Ans. c (HDL). (Ref. Harper, Biochemistry, 25th/pg.270)LIPOPROTEINFUNCTIONSChylomicron- Delivers dietary triglycerides to peripheral tissues and dietary cholesterol to liver.- Secreted by intestinal epithelial cells.- Levels are classically increased in lipoprotein lipase deficiency.0- Excess causes pancreatitis, lipemia retinalis, and eruptive xanthomas.VLDL- Delivers hepatic triglycerides to peripheral tissues.- Secreted by liver.- Excess causes pancreatitis.LDL- Delivers hepatic cholesterol to peripheral tissues.- Formed by lipoprotein lipase modification of VLDL in the peripheral tissue.- Taken up by target cells via receptor-mediated endocytosis.- Classically increased in familial hypercholesterolemia.- Most atherogenic.0HDL- So called 'good cholesterol'(anti-atherogenic).- Mediates centripetal transport of cholesterol (reverse cholesterol transport).- Acts as a precursor for apoC and apoE (which are needed for chylomicron and VLDL metabolism).- Secreted from both liver and intestine. # Lowest density lipoprotein with largest size>> Chylomicrons.# Highest cholesterol containing lipoprotein (50%)>> LDL.# Least cholesterol containing lipoprotein (5%)>> Chylomicrons.# Highest triacyglycerol containing lipoprotein>> Chylomicromins.# Highest protein containing lipoprotein>> HDL (2) albumin FFA (1).# Least protein containing lipoprotein>> Chylomicrons.# Least triacyl glycerol containing lipoprotein (3%)>> HDL.# Highest phospholipid containing lipoprotein>> HDL.# Exogeous lipid transport from intestine to liver & extrahepatic tissues through>> Chylomicrons.# Endogeous lipid transport is from liver to extrahepatic tissues via>> VLDL.# Reverse cholesterol transport is from extrahepatic tissues to liver via>> HDL.# Essential fatty acids are arachidonic acid.>> Linoleic acid, lenolenic acid &# Fatty acid chain with ?1 double bonds are unsaturated fatty acids, e.g., linoleic acid--18:2, lenolenic acid--18:3, arachidonic acid--20:4.e>> Oleic acid,
Category:
Biochemistry
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now