Familial polyposis coli is associated with following genetic defect?

Correct Answer: APC
Description: Ans is ;c' i.e., APC * Familial adenomatous polyposis (FAP) syndrome (familial polyposis coli) is caused by mutation in adenomatous polyposis coli gene(APC) located on long arm of chromosome 5 (5q21). Risk of malignancy is 100%, i.e. all patients develop colorectal carcinoma if left untreated.
Category: Pathology
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