Most useful maternal serum test used for distinguishing open neural tube defects and ventral wall defect in a fetus?
Correct Answer: Acetylcholinesterase
Description: Acetylcholinesterase is derived mostly from the tissues of the fetal nervous system. Amniotic fluid acetylcholinesterase is a biochemical marker that is positive in 95% fetuses with open neural tube defects. When both AFP and AChE is positive, likelihood of an open spine defect is greater than 99.5%. High acetylcholinesterase and low butrylcholinesterase in seen in open neural tube defect. Opposite occur in open ventral wall defect. Ref: Clinical Laboratory Medicine By Kenneth D. McClatchey, 2nd Edition, Page 644 ; Genetic Disorders and The Fetus: Diagnosis, Prevention and Treatment Edited By Aubrey Milunsky, 6th Edition ; Diseases of The Liver and Biliary System in Children By Deirdre A. Kelly, 3rd Edition, Page 306 ; Fundamentals of Surgical Practice By A. N. Kingsnoh, 2nd Edition, Page 172
Category:
Gynaecology & Obstetrics
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now