Dinitrophenol causes
Correct Answer: Uncoupling of oxidation and phosphorylation
Description: Mechanism of Action of DNP as uncoupler Dinitrophenol (DNP) a potent uncoupler is ampipathic and increase the permeability of the lipoid inner mitochondrial membrane to protons (H+), thus reducing the electrochemical potential and sho-circuiting the ATP synthase. In this way, oxidation can proceed without phosphorylation. Note: DNP was used for weight loss. But it was discontinued due to hypehermia and other side effects.Ref: MN Chatterjea Textbook of Medical Biochemistry, 8th edition, page no: 146
Category:
Biochemistry
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