Viral enterotoxin is detected as a possible mechanism of pathogenesis in :
Correct Answer: Rota virus
Description: Mechanism of Rotavirus diarrhea :
a. Rotavirus destroy mature enterocytes of proximal small intestine.
Loss of absorptive villi and proliferation of secretory crypt cells
– Secretory diarrhea
Brush border enzymes are reduced so unmetabolized disaccharides accumulates resulting.
– Osmotic diarrhea
b. NSP4 = enterotoxin which alteres epithelial cell function and permeability causing secretory diarrhea.
c. Virus evoke fluid secretion by the activation of enteric nervous system in intestinal wall.
Category:
Microbiology
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