Hypeension with Hypokalemia is seen in:
Correct Answer: Liddle's Syndrome
Description: Liddle&;s Syndrome is typically associated with Hypokalemia and Hypeension. Rater&;s Syndrome and Gitelman&;s Syndrome are also associated with hypokalemia but without hypeension. Liddle&;s Syndrome : Review Pathophysiology: * Autosomal dominant disorder. * Genetic defect in the collecting tubule sodium channel, resulting in increased sodium reabsorption and lack of inhibition by higher levels of intracellular sodium Age of Presentation * Often diagnosed at young age, but can present in adulthood due to phenotypic variation. Clinical presentation * Classic triad of hypeension, metabolic alkalosis, and hypokalemia. * Consider iffamily history of hypeension and/or hypokalemia. at young age Lab data * Metabolic alkalosis, hrpokalemia (although some are low normal), low urinary aldosterone secretion Treatment: * Lifelong. Potassium-sparing diuretic which closes the sodium channel (Amiloride or Triamterene). Spironolactone does not work.
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