What is the mechanism of acute rheumatic lever –
Correct Answer: Cross reactivity with host antigen
Description: Rheumatic fever is an acute, immunologically mediated, multisystem inflammatory disease that occurs after group A b-hemolytic streptococcal infections (usually pharyngitis, but also rarely with infections at other sites such as skin). Rheumatic hea disease is the cardiac manifestation of rheumatic fever. Acute rheumatic fever is a hypersensitivity reaction classically attributed to antibodies directed against group A streptococcal molecules that also are cross-reactive with host antigens. (Robbins basic pathology,9th edition,pg no.391)
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Pathology
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