Which of the following is used in first trimester screening for Down’s syndrome?
Correct Answer: PAPP-A
Description: Down&;s syndrome ScreeningUSG markersMaternal age - Age >35, screening test is offered.Biochemical testsUltrasonographyFirst trimester screening for Down&;s syndromePAPP-A. hCG (biochemical tests)NT (nuchal translucency) (USG)PAPP-A pregnancy-associated plasma protein-decreases in Down&;s syndromeSerum beta hCG - elevated in Down&;s syndromeNuchal translucency increases in aneuploid fetus in first trimester: 3.5 mm is significant done at 11-14 weeksSensitivity of combined NT thickness and 1st trimesterbiochemical tests is 90%.Second trimester screening for Down&;s syndromeTriple test and quadruple tests are done in second trimester at 15-20 weeksTriple test: hCG, AFP, unconjugated estriolQuadruple test: Triple test + inhibinNuchal fold thickeningMild renal pelvis dilatationEchogenic intracardiac focusEchogenic bowelSho femurSho humerus(Refer: Mudaliar and Menon&;s Clinical Obstetrics, 11th edition, pg no: 466)
Category:
Anatomy
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now