Which of the following HLA subtype is most characteristically associated with Rheumatoid ahritis:
Correct Answer: HLADR4
Description: Answer is D (HLA-DR4): Rheumatoid ahritis is associated with multiple HLA-DR subtypes, but the strongest association has been repoed with HLA DR4 The class II MHC allele HLA DR4 and related alleles are knkwn to be major genetic risk factors for RA' - Harrison HLA and Rheumatoid Ahirits * Rheumatoid Ahritis is strongly associated with specific HLA class II markers (Rheumatoid Ahritis is only weakly associated with HLA class I marker) * Rheumatoid Ahritis is associated with multiple HLA subtype encoded by the HLADRB 1 gene Multiple HLA subtypes that are associated with RA (HLA DRB1 gene) HLA DR4 (strongest association in general) HLA DR 1 HLA DR 6 HLA DR 9 HLA DR 10 HLA DR 14 * In different ethnic groups HLA DR1, HLA DR4, HLA DR6, HLA DR9, HLA-DR 10, HLA DR-14 molecules have been associated with RA. * Ceain HLA DR alleles may protect against development of RA. HLADR Alleles that may protect against development of RA HLA DR 2 HLA DR 3 HLA DR 5 HLA DR 7
Category:
Medicine
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now