Histopathological examination reveals the diagnosis as:
Correct Answer: Hodgkin lymphoma
Description: Characteristic malignant cells of Hodgkin’s diseases are large cells known as Reed–Sternberg (RS) cells (typical and variant), 20–50 micrometers in diameter, abundant, amphophilic, finely granular/homogeneous cytoplasm; two mirror-image nuclei (owl eyes) each with an eosinophilic nucleolus and a thick nuclear membrane (chromatin is distributed at the cell periphery). One or two percent of these malignant cells are admixed within a reactive cell infiltrate composed of variable proportions of lymphocytes, histiocytes, eosinophils, and plasma cells. The Reed–Sternberg cells are identified as large often binucleated cells with prominent nucleoli and an unusual CD15+, CD30+ immunophenotype. In approximately 50% of cases, the Reed–Sternberg cells are infected by the Epstein-Barr virus.
Ref: Shafer’s Ed 7th Pg 187
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now