In Phenylketonuria the main aim of first-line therapy is
Correct Answer: Limiting the substrate for deficient enzyme
Description: In PKU Phenylalanine hydroxylase enzyme is deficient.So alternative pathways are opened. Leading to the formation of Phenylketone,Phenyllactate and Phenylacetate. This can be prevented by limiting the substrate for deficient enzyme.Ref: DM Vasudevan - Textbook of Biochemistry, 7th edition, page no: 236
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