ALL L3 morphology is a malignancy arising from which cell lineage –
Correct Answer: Mature B cell
Description: Cellular classification of ALL
French-American-British (FAB) system divides ALL into three morphological subtypes.
i) LI lymphoblasts
Most common type (80-85%)
Cells have scanty cytoplasm and inconspicuous nucleoli.
Have better prognosis
ii) L2 lymphoblasts
Cells are large and more pleomorphic in size with more abundant cytoplasm and prominent nucleoli.
iii) L3 - lymphoblast
Least common
Morphology is identical to urkitt's lymphoma cells i.e., mature B cells with surface immunoglobulin positive.
Category:
Pediatrics
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