Which intermediate of citric acid cycle is used in detoxification of ammonia in brain?
Correct Answer: Alpha-ketoglutarate
Description: When ammonia is present in body in large amount (hyperammonemia), then this alpha-ketoglutarate of TCA combines with one amino group to form glutamate Fuher glutamate combines with the second amino group to form glutamine Glutamine is a safe form of ammonia storage & transpo. Alpha-ketoglutarate is depleted, which affects TCA cycle. That's why brain is affected as the first organ (Brain is highly aerobic tissue).
Category:
Biochemistry
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now