Which of the following enzymic activities would you expect to be decreased in thiamine deficiency?
Correct Answer: a-Ketoglutarate dehydrogenase
Description: In the reaction catalyzed by a-ketoglutarate dehydrogenase complex, thiamine pyrophosphate, the cofactor form of thiamine, functions as a transient carrier of the five-carbon intermediate produced on decarboxylation of a-ketoglutrate. Biotin is a coenzyme of pyruvate carboxylase. Isocitrate dehydrogenase use NAD+ as coenzymes, whereas fumarase has no coenzyme. Ref: Brooks G.F. (2013). Chapter 6. Microbial Metabolism. In G.F. Brooks (Ed),Jawetz, Melnick, & Adelberg's Medical Microbiology, 26e.
Category:
Biochemistry
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now