A 30 year old female patient complains of weakness and fatigue. Patient gives history of consumption of antiepileptic drugs and is also a lactating mother. Lab investigation reveals Hb-8gm% and presence of macrocytic RBCs on peripheral blood smear. This patient may be suffering from deficiency of-
Correct Answer: Vitamin B9
Description: The folic acid deficiency(vitamin B9) may be due to (one or more causes) inadequate dietary intake, defective absorption, use of anti convulsant drugs (phenobarbitone, dilantin, phenytoin), and increased demand.
The rapidly dividing cells of bone marrow are seriously affected.
The macrocytic anemia (abnormally large RBC) associated with megaloblastic changes in bone marrow is a characteristic feature of folate deficiency.
Satyanarayana- Biochemistry, 3rd edition, pg-152
Category:
Biochemistry
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