Endogenous pyrogens act by ?
Correct Answer: Raising thermostat point of hypothalamus
Description: Ans. is 'b' i.e., Raising thermostat point of hypothalamusBacterial toxins (exogenous pyrogens) stimulate inflammatory cells to secrete pyrogenic cytokines (endogenous pyrogens), e.g. IL-I, TNF-a , and IL-6.These endogenous pyrogenes stimulate PGE2 release in hypothalamus, which raises temperature set point of hypothalamus to cause fever.
Category:
Physiology
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